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One of the immunosuppressive mechanisms triggered by some tumors to bypass immune response and responsible of immune checkpoint inhibitor treatment failure, is based on regulatory T cells (Tregs). In the tumor microenvironment (TME), Tregs facilitate self-tolerance by suppressing effector immune function (T and NK cells) through inhibitory cytokines, thereby limiting the antigen-specific immune response. Infiltrated within the tumor, Tregs act as brakes on the anti-tumor immunity. Therefore, targeting Treg receptors specifically overexpressed in the context of cancer constitutes a promising approach in cancer immunotherapy.


Program description

Anti-CCR8 antibody

  • Discovery
  • Candidate
  • Preclinical
  • Clinical

Using our cross-validated strategy, Domain identified the C-C motif chemokine receptor 8 (CCR8) as a major target specifically overexpressed in a context of tumors resistant to immune checkpoint inhibitors.

Based on this data and a solid proof of principle package, we have launched and progressed a program aiming at bringing to the clinic a monoclonal antibody targeting CCR8 to deplete tumor infiltrated Tregs and restore immunosurveillance.

The program is currently at the discovery stage.

 

 


Other programs

Undisclosed GPCR targets

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EP4R antagonist (DT-9081)

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