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In 2015, Domain Therapeutics launched Kaldion, a IP holding company, to harness the potential of its adenosine programs. Kaldion granted its first license to CleveXel Pharma, who will develop a preclinical candidate for Parkinson’s disease. In 2017, Kaldion granted an exclusive license to Domain to develop A2AR antagonists in immuno-oncology in collaboration with Merck (see press release).

Program description

Adenosine A2AR antagonists (exit)

  • Discovery
  • Candidate
  • Preclinical
  • Clinical

Other Programs

New GPCRs target identification and validation

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Sema3A fusion protein for immuno-oncology

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