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Logo RHU Condor against Sarcoma

 

CONDOR is a unique approach aiming to deliver a therapeutic arsenal based on better knowledge of the Soft Tissue Sarcoma (STS) tumor microenvironment, predictive tools and biomarkers to stratify patients, as well as new immunotherapeutic approaches. The ultimate goal is to double the life expectancy of patients with metastatic STS and develop new immunotherapies targeting GPCRs involved in the immune responses to STS.

In the course of RHU CONDOR, Domain will develop three therapeutic programs targeting GPCRs involved in resistance to immune checkpoint inhibitors in sarcoma patients by running a phase 1b with DT-9081 (EP4 receptor antagonist) in combination with an immune checkpoint inhibitor and progressing two discovery assets with the objective of delivering candidates ready for regulatory development for STS.


Program description

Precision Medicine and Immunotherapy of Sarcoma

  • Discovery
  • Candidate
  • Preclinical
  • Clinical

 In 2022, Domain Therapeutics, Institut Bergonié, Explicyte, Owkin, Centre de Recherche des Cordeliers, the Institut Gustave Roussy, the Centre Léon Bérard and Inserm entered into a collaboration consortium through the hospital-university research in health (RHU CONDOR project). This 5-year consortium addressing precision medicine and immunotherapy of sarcoma is backed to a 30M€ budget and will benefit of a 10M€ financial support.

 


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Multi-target collaboration for CNS

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Multi-target collaboration for rare diseases

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