Use of novel ebBRET biosensors for comprehensive signaling profiling of 100 therapeutically relevant human GPCRs

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Use of novel ebBRET biosensors for comprehensive signaling profiling of one hundred therapeutically relevant human GPCRs

Here, we describe a novel suite of enhanced bystander bioluminescence resonance energy transfer (ebBRET)-based biosensors that were used to define the signaling profiles of 100 therapeutically relevant human GPCRs in response to endogenous (or prototypical) ligands.