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A pan group III mGluR PAM candidate ready to enter pre-IND studies

By targeting not only mGluR4 but also mGluR7 and 8, and by exhibiting an improved oral PK profile, DT095435 is positioned as a second generation compound that should succeed in reaching clinical efficacy where Foliglurax narrowly failed.

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A reliable real time pharmacological platform dedicated to the study of ICP co-receptors

This poster presents bioSens-All®️, a powerful and versatile pharmacological platform which is highly adaptable for hot topic targets such as Immune Checkpoint targets (Inhibitory & Stimulatory Immune Checkpoints).

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Use of novel ebBRET biosensors for comprehensive signaling profiling of 100 therapeutically relevant human GPCRs

Here, we describe a novel suite of enhanced bystander bioluminescence resonance energy transfer (ebBRET)-based biosensors that were used to define the signaling profiles of 100 therapeutically relevant human GPCRs in response to endogenous (or prototypical) ligands.

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A high value pharmacological platform dedicated to the real time study of Stimulatory immune checkpoint signaling pathways

We present here several innovative BRET assays dedicated to inhibitory and stimulatory ICPs (PD-1, CTLA-4, 4-1BB), and developed by us.
The ICP platform set up here shows good accuracy & robustness and represents a solid & reliable technology for ICP dedicated drug discovery.

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A pharmacological platform for the real time study of ICP signaling pathways

This poster presents the last generation of our proprietary platform bioSens-All®️ which is dedicated to the identification and characterization of immune checkpoint inhibitors.

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DT095597 a New NPFFR1 Antagonist Devoid of Addictive Properties to Fight Opioid Crisis

This poster presents the characterization of a proprietary NPFF receptor antagonist as a game-changer and a promising therapeutic strategy to fight the current opioid crisis.

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Decrypting EGFR signaling with BRET biosensors : A novel approach to study RTK mutations and the effects of inhibitors

This poster illustrates a valuable BRET-based platform used to characterize RTK candidates regarding constitutive activity, real-time kinetics or impact of RTK mutations on signalling pathways.

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“GPCR-ome” modulation upon PD1 / PDL1 axis blockade

co-authored with Explicyte, Bordeaux, France & Institut Bergonié, Bordeaux, France, this poster discloses an in-depth GPCR expression analysis from tumor microenvironment to dissect out mechanisms of resistance to immune checkpoint inhibitors.

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DT095895, a selective EP4 receptor antagonist with monotherapy efficacy in syngeneic mouse model(s) and best-in-class properties

This poster presents the complete characterization of Domain drug candidate benchmarked to EP4 antagonist molecules currently in the clinic and demonstrating a best-in-class potential.

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DT095435: A novel “pan” group III metabotropic glutamate receptor positive allosteric modulator for Parkinson’s disease

This poster presents the profiling of DT095435, our pan group III mGluR PAM development candidate, as a potential new anti-dyskinetic treatment for Parkinson's disease.

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Creation of a large-spectrum GPCR biosensor for functional in vitro safety and systems pharmacology analysis

This study served as a validation of the utility of the Gz/G15 large-spectrum biosensor for safety and systems pharmacology profiling. Moreover, our results support the use of this cell-based functional assay in high throughput receptor deorphanization and functional screening programs.

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GPCRs in oncology and immuno-oncology : The IRIC's virtual symposium 2021 [VIDEO]

Chaired by IRIC's CEO Michel Bouvier, this symposium showcases some of the latest discoveries & techniques leveraging the potential of GPCRs in oncology and immuno-oncology.
Leading experts share findings from world-class academic & private research on GPCRs in those crucial fields.

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The discovery and challenges of antibodies targeting GPCRs. [WEBINAR]

Xavier Leroy, Domain Therapeutics's CSO, Xavier Leroy and Martine Smit, Professor of Target and Systems Biochemistry at the University of Amsterdam, discuss the progress achieved in G protein-coupled receptor (GPCR) therapeutic antibody-based discovery and development.

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[Summary] The IRIC Virtual Symposium : “GPCRs In Oncology & Immuno-oncology” – Sponsored by Domain Therapeutics

A summary of the symposium that took place on June 4.
Chaired by IRIC's CEO Michel Bouvier, it showcases some of the latest discoveries & techniques leveraging the potential of GPCRs in oncology and immuno-oncology.

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