Creation of a large-spectrum GPCR biosensor for functional in vitro safety and systems pharmacology analysis

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Creation of a large-spectrum GPCR biosensor for functional in vitro safety and systems pharmacology analysis

This study served as a validation of the utility of the Gz/G15 large-spectrum biosensor for safety and systems pharmacology profiling. Moreover, our results support the use of this cell-based functional assay in high throughput receptor deorphanization and functional screening programs.