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   PARTNERING

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    Partnering

    Merck KGaA

    Merck KGaA

    In 2017, Domain Therapeutics and Merck KGaA (Darmstadt, Germany) entered into collaboration and licensing agreement for the development of adenosine receptor antagonist drugs specifically designed for oncology and immuno-oncology. Merck will support research activities and gain worldwide rights to Domain Therapeutics’ next generation of adenosine receptor inhibitors. Under the terms of the agreement, Domain will be eligible for more than EUR 240 million in milestones, as well as undisclosed royalties.


    PRESS RELEASE: Domain Therapeutics and Merck enter into a license and collaboration agreement for development of adenosine receptor antagonists in immuno-oncology


    Status: on-going

    Mavalon

    Mavalon

    In 2016, Domain Therapeutics and Medicxi, a Swiss venture fund dedicated to financing asset-centric companies, created Mavalon Therapeutics, a company focused on stopping the progression of Parkinson’s disease. Mavalon Therapeutics is developing the first orally available small molecule able to induce GDNF production within the brain of Parkinson’s patients. GDNF is a naturally occurring factor promoting the growth of dopamine neurons. The drug candidate, a positive allosteric modulator of the metabotropic glutamate receptor type 3 (mGluR3 PAM), was discovered and initially developed by Domain Therapeutics with the support of the Michael J. Fox Foundation. Medixci committed up to €9m ($10m) in Mavalon.


    PRESS RELEASE: Domain Therapeutics and Medicxi launch Mavalon Therapeutics


    Status: on-going

    Prexton Therapeutics

    Prexton Therapeutics

    In 2012, Domain Therapeutics has granted Prexton Therapeutics (Geneva - Switzerland) an exclusive option to license and develop metabotropic glutamate receptor 4 (mGluR4) Positive Allosteric Modulator (PAM) drugs targeting Parkinson’s disease. The chemical series was previously developed through a licensing and collaboration agreement signed between Domain and Merck Serono, a division of Merck (Darmstadt - Germany) in January 2011. Under the terms of the initial agreement between Domain Therapeutics and Prexton Therapeutics - a spin-off company of Merck Serono - Prexton benefited from an exclusive license option to progress the mGluR4 PAM drug candidates into clinical development. After having exercised the exclusive option, Prexton entered into license agreement with Domain Therapeutics, selected an mGluR4 PAM candidate, PXT002331, and conducted regulatory preclinical development and Phase I. In September 2016, Prexton announced the successful completion of the Phase I clinical trial.


    PRESS RELEASE: Domain Therapeutics grants Prexton Therapeutics an exclusive option to license and develop mGluR4 PAMs for Parkinson’s Disease

    PRESS RELEASE: Prexton Therapeutics completes phase 1 clinical trial with PXT002331


    Status: on-going

    ONO Pharmaceutical

    ONO Pharmaceutical

    In 2012, Domain and Ono Pharmaceutical Co., Ltd. (Osaka - Japan) signed a collaboration agreement focused on discovering small molecules targeting G-Protein Coupled Receptors (GPCRs). Under the agreement, Ono will pay to Domain Therapeutics upfront payment, research funding for the collaborative research programs, success-based milestones on the research and development progress, as well as royalties on sales of the products. Domain Therapeutics will apply DTect-All™, its proprietary GPCR drug discovery platform and its expertise in GPCR medicinal chemistry and pharmacology to design and optimize small molecules into drug candidates having activity against GPCRs selected by Ono. Ono will have worldwide exclusive rights to develop and commercialize any pharmaceutical product arising out of the drug discovery collaboration.


    PRESS RELEASE: Domain Therapeutics Enters into Collaboration Agreement with Ono in the Field of GPCR-Based Drug Discovery


    Status: completed

    Merck Serono

    Merck Serono

    In 2011, Domain Therapeutics signed an exclusive development and licensing agreement with Merck Serono, a division of Merck KGaA, Darmstadt, Germany, to develop metabotropic glutamate receptor 4 (mGluR4) Positive Allosteric Modulator (PAM) drugs targeting Parkinson’s disease and other neurodegenerative diseases. Domain Therapeutics has contributed optimized compounds that have been developed from its proprietary chemical series. Under the terms of the agreement, the company has received EUR 2 million in upfront payment and research funding, and was eligible for up to EUR 132 million in milestones for the first two products, as well as undisclosed royalties.


    PRESS RELEASE: Domain Therapeutics and Merck Serono Announce an Agreement to Develop Drugs for Parkinson’s Disease


    Status: completed

    Takeda Pharmaceutical

    Takeda

    In 2008, Domain Therapeutics signed a research agreement with Takeda Pharmaceutical Company Limited, Japan's largest pharmaceutical company. Under the agreement, Domain Therapeutics applied its Dtect-All™ platform to identify novel drug candidates that target undisclosed G Protein-Coupled Receptors (GPCRs) of interest to Takeda. In 2009 Domain Therapeutics announced that it has successfully completed the first milestone in this research agreement with Takeda Pharmaceutical. Following milestone completion have not been publicly announced.


    PRESS RELEASE: Domain Therapeutics announces successful completion of the first milestone in its Research Agreement with Takeda Pharmaceutical


    Status: completed